Rapid expansion of highly functional antigen-specific T cells from patients with melanoma by nanoscale artificial antigen-presenting cells
J Ichikawa, T Yoshida, A Isser, AS Laino… - Clinical Cancer …, 2020 - AACR
… Combined, these cellular attributes characterize T cells with antitumor properties that may
… IL4, IL5, and IL13 were detected in response to peptide-pulsed T2 cells but not to control T2 …
… IL4, IL5, and IL13 were detected in response to peptide-pulsed T2 cells but not to control T2 …
Selective STING stimulation in dendritic cells primes antitumor T cell responses
B Jneid, A Bochnakian, C Hoffmann, F Delisle… - Science …, 2023 - science.org
… strategy to enhance T cell–targeted immunotherapy. … of synthetic CDNs that activate STING
stimulates antitumor … into the induction of IFNs by antigen-presenting cells, we treated bone …
stimulates antitumor … into the induction of IFNs by antigen-presenting cells, we treated bone …
Intranasal delivery of cationic liposome-protamine complex mRNA vaccine elicits effective anti-tumor immunity
Y Mai, J Guo, Y Zhao, S Ma, Y Hou, J Yang - Cellular Immunology, 2020 - Elsevier
… Immunization with synthetic mRNA encoding tumor-… antigen-presenting cells antigen
presentation, and induce an … a more effective protective antitumor effect. Furthermore, our …
presentation, and induce an … a more effective protective antitumor effect. Furthermore, our …
[HTML][HTML] Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine
EA Melgoza-González, L Bustamante-Córdova… - Frontiers in …, 2023 - frontiersin.org
… Different approaches using antibodies, natural or synthetic ligands… effectively elicited a robust
and protective immune response … as a model to elicit an antitumoral response in dogs. The …
and protective immune response … as a model to elicit an antitumoral response in dogs. The …
Bioinspired vaccines to enhance MHC class-I antigen cross-presentation
… synthetic vaccines can be engineered to enhance MHC-I presentation of exogenous peptide
and protein antigens by professional antigen-presenting cells (… + T cell‐targeted vaccines. …
and protein antigens by professional antigen-presenting cells (… + T cell‐targeted vaccines. …
[HTML][HTML] Strategies to use nanoparticles to generate CD4 and CD8 regulatory T cells for the treatment of SLE and other autoimmune diseases
DA Horwitz, S Bickerton, A La Cava - Frontiers in Immunology, 2021 - frontiersin.org
… T cell targeted nanoparticles have been formulated to act as tolerogenic artificial antigen
presenting cells… viruses and pathogens that elicit or subvert immune responses are, in essence, …
presenting cells… viruses and pathogens that elicit or subvert immune responses are, in essence, …
A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8+ T Cell Epitopes
… immune responses at nanogram dosing. Along with CoPoP (… better taken up by antigen-presenting
cells, where they were … protection rate is in accordance to the Ag-specific CD8 + T …
cells, where they were … protection rate is in accordance to the Ag-specific CD8 + T …
Antigen identification for HLA class I–and HLA class II–restricted T cell receptors using cytokine-capturing antigen-presenting cells
MN Lee, M Meyerson - Science immunology, 2021 - science.org
… in disease contexts such as cancer and natural/vaccine-elicited … sets due to the high
costs of peptide synthesis (15, 16). … 1A) and uses a cytokine readout to pinpoint T cell–targeted …
costs of peptide synthesis (15, 16). … 1A) and uses a cytokine readout to pinpoint T cell–targeted …
[HTML][HTML] Biomaterial-based activation and expansion of tumor-specific T cells
… anti-tumor responses (10, 11). It is therefore evident that … of synthetic, acellular artificial antigen
presenting cells (aAPCs) … to develop biomaterial designs that can elicit long-term memory …
presenting cells (aAPCs) … to develop biomaterial designs that can elicit long-term memory …
Immunotherapy targeting tumor‐associated antigen in a mouse model of head and neck cancer
…, T Kumai, H Yamaki, R Sato, T Nagato, T Ohkuri… - Head & …, 2024 - Wiley Online Library
… -specific T cell responses in a non-artificial mouse model. … recognized by T cells in the context
of antigen-presenting molecules… with CD4 + T cell-targeted vaccine shows better antitumor …
of antigen-presenting molecules… with CD4 + T cell-targeted vaccine shows better antitumor …